AAPS–FIP Summary Workshop Report: Pharmacogenetics in Individualized Medicine: Methods, Regulatory, and Clinical Applications
نویسندگان
چکیده
منابع مشابه
Pharmacogenetics, pharmacogenomics, and individualized medicine.
Individual variability in drug efficacy and drug safety is a major challenge in current clinical practice, drug development, and drug regulation. For more than 5 decades, studies of pharmacogenetics have provided ample examples of causal relations between genotypes and drug response to account for phenotypic variations of clinical importance in drug therapy. The convergence of pharmacogenetics ...
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Pharmacogenetics, the study of genetic variation relevant to drug metabolism, is a rapidly evolving area of medicine. This brief review will consider some of the recent advances where inherited genetic variants have been associated with either drug efficacy or toxicity. Examples of where pharmacogenetic testing has been adopted into clinical practice will be provided as well as a look at its li...
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pancreatic cancer (pc) is a progressive, fatal disease with a high degree of malignancy. more than 40000 peoplediefrom this cancer annually in the united states. as a multifactorial condition, pc has a complex nature, and there are several genes and signalingpathwaysimplicated in pc pathogenesis and progression. there are diffèrent mutations in master genesincludingtumorsuppressors and oncogene...
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RISKS TO THE ENVIRONMENT AND SOCIETY POSED BY RESISTANT PESTS Many general questions and observations were made concerning the risk of pests, especially insect pests to a crop containing a transgenic pesticide, e.g., the Bacillus thuringiensis (Bt) toxin. If pests cannot be controlled, food and fiber crops will be jeopardized and may negatively impact society throughout the world. As a result, ...
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Adverse drug reactions (ADRs) are a major problem in drug therapy and drug development. Inter-individual genetic differences can have significant roles in determining an individual’s susceptibility to ADRs. The rapid development of techniques in the area of genome analysis has put the scientific community in a power position and facilitated identification of new pharmacogenomic biomarkers that ...
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ژورنال
عنوان ژورنال: The AAPS Journal
سال: 2009
ISSN: 1550-7416
DOI: 10.1208/s12248-009-9097-0